PI- Dr. David Geller, Dr. Bang Hoang, Dr. Rui Yang

Lab Personnel’s: Fnu Hasibagan, Ranxin Zhang, Waleed Al-Harden, Janet Tingling

Posters and Abstracts

1. Yang, R., Falk, A., Wang, J., Sen, M., Hoang, B., Geller, D. Percutaneous Screw Application on Pelvis: Can We Treat Pelvic Metastatic Cancer Using Trauma Principles.  AAOS Annual Meeting. Submitted. March 22-26, 2021
2. Wang, J., Aldehamsheh, O., Ferrena, A., Singh, S., Borjihan, H., Yaguare, S., Viscarret, V., Tingling, J., Zi, X., Lo, Y., Gorlick, R., Zheng, D., Schwartz, E. L., Zhao, H., Yang, R., Geller, D., Hoang, B. The interaction of SKP2 with p27 enhances the progression and stemness of osteosarcoma. AACR Annual Meeting. Philadelphia, PA. April 10-15, 2021
3. Yang, R., Falk, A., Wang, J., Sen, M., Hoang, B., Geller, D. Percutaneous Screw Application on Pelvis: Can We Treat Pelvic Metastatic Cancer Using Trauma Principles.  13th Annual Asian Pacific Musculoskeletal Tumor Society. # A-3-1-4. April 21-23, 2021. Virtual Presentation
4. Weiser, D., Geller, D., Treiser, M., Oliver-Krasinski, J., Ewart, M., Lee, D. A case of infantile fibrosarcoma treated with neoadjuvant larotrectinib. American Academy of Dermatology 26240. Accepted. April 23-25, 2021. Virtual Abstract
5. Wang, J., Aldahamsheh, O., Ferrena, A., Borjihan, H., Singla, A., Yaguare, S., Singh, S., Viscarret, V., Tingling, J., Zi, X., Lo, Y., Gorlick, R., Zheng, D., Schwartz, E.L., Zhao, H., Yang, R., Geller, D., Hoang, B. The Interaction of Skp2 With P27 Enhances in the Progression and Tumor-initiating Properties of Osteosarcoma. AAOS Annual Meeting.. Accepted. September 4, 2021
6. Volaski, H., Brook, A., Viscarret, V., Wang, J., Singh, S., Yang, R., Hoang, B., Tingling, J., Al-Hardan, W., Zhang, R., Thornhill, B., Geller, D. Benign Bone Lesions: Do They Warrant Follow-Up? Annual Musculoskeletal Tumor Society Meeting. Baltimore, MD. October 6-8, 2021
7. Wang, J., Singh, S., Ferrena, A., Zhao, H., Viscarret, V., Borjihan, H., Tingling, J., Yang, R., Geller, D., and Hoang, B. Targeted Inhibition of SCF SKP2 Complex Has Antitumor Activity on Osteosarcoma Organoids. Annual Musculoskeletal Tumor Society Meeting. Baltimore, MD. October 6-8, 2021.
8. Wang, J., Singh, S., Ferrena, A., Zhao, H., Viscarret, V., Borjihan, H., Tingling, J., Yang, R., Geller, D., and Hoang, B. A targeted inhibition of the E3 ligase SCFSkp2/Cks1 has survival benefit and antitumor activity in osteosarcoma. Annual Musculoskeletal Tumor Society Meeting. Baltimore, MD. October 6-8, 2021.
9. Peraza, J., Chai, J., Hoang, B., Yang, R., Geller, D., Frager, S., Paoluzzi, L. Drug-Induced Liver Injury Associated with Pexidartinib Treatment for Tenosynovial Giant Cell Tumor. ACG Annual Meeting. Las Vegas, NV. Poster Presentation. Accepted. October 22-27, 2021

Accepted Journals

1. Ugur, E., Doshi, H., Levine, N., Tingling, J., Yang, R.Y., Hoang, B., Geller,  D., Yang R. (2021). Can the Katagiri Scoring System Predict Prognosis for Surgically-Managed Patients with Metastatic Bone Disease? Ann Joint. 6(29). doi.org/10.21037/aoj-20-111
2. Ugur, E., Volaski, H., Yang, R., Hoang, B., Levine, N., Singh, S., Wang, J., Geller, D. (2021).Variability in the reported surgical techniques and methods for intercalary reconstruction following tumor resection. Surg Oncol. 38:101610. doi: 10.1016/j.suronc.2021.101610
3. Mackey, C., Wake, N., Hoang, B., Yang, R., Aldahamsheh, O., Geller, D. S. (2021). A case report describing pre-operative contouring of an orthopedic implant using a 3D-printed patient-specific model. J of Ortho Case Reports. doi:10.13107/jocr.2021.v11.i06.2244
4. Viscarret, V., Mahali, L., Volaski, H., Tingling, J., Yaguare, S., Yang, R., Geller, D. (2021). Management of Bilateral Humeral Pathologic Fracture in Metastatic Anaplastic Hemangiopericytoma and Doege-Potter Syndrome: A Case Report and Review of the Literature. World Journal of Surgery and Surgical Research. 4:1301.
5. Schneider, P., Heels-Ansdell, D., Thabane, L. et al. (2021). Prophylactic Antibiotic Regimens In Tumor Surgery (PARITY): a multi-center randomized controlled study comparing alternative antibiotic regimens in patients undergoing tumor resections with endoprosthetic replacements—a statistical analysis plan. Trials 22, 223 doi.org/10.1186/s13063-021-05147-2.
6. Yang R, Wang J, Mizera, M., Tarpada S., Seetharaman, M., Sen, M., Hoang, B., Geller D. (2021). A graphic guide to the percutaneous tripod acetabular reconstruction for metastatic cancer. J Surg Oncol. 123(5):1316-1327. doi:10.1002/jso.26409.
7. Wang, J., Aldahamsheh, O., Ferrena, A., Borjihan, H., Singla, A., Yaguare, S., Singh, S., Viscarret, V., Tingling, J., Zi, X., Lo, Y., Gorlick, R., Zheng, D., Schwartz, E., Zhao, H., Yang, R., Geller, D., Hoang, B. (2021). The interaction of SKP2 with p27 enhances the progression and stemness of osteosarcoma. Ann. N.Y. Acad. Sci., 1490(1):90-104. doi.org/10.1111/nyas.14578. PMID: 33594717.
8. Zvi, Y., Ugur, E., Batko, B., Gill, J., Roth M, Gorlick, R., Hall, D., Tingling, J., Barkauskas, D.,  Zhang, J., Yang, R., Yang, J., Hoang, B., Geller, D. (2021). Prognostic and Therapeutic Utility of Variably Expressed Cell Surface Receptors in Osteosarcoma. Sarcoma. 2021, doi: 10.1155/2021/8324348. PMID 33603563.
9. Du, W., Wang, J., Xu, J., Zhao, Z., Liu, S., Yang, L., Yang, R., Wang, S., Guo, W. (2021) Comparison and modification of survival predicting system for breast cancer patients with bone metastases. Ann Joint, 6:28. doi:10.21037/aoj-20-120
10. Peraza, J.,  Rahman, S.,  De-Oliviera, D., Yibirin, M., Chai, J., Frager, S., Geller, D., Yang, R., Hoang, B., Paoluzzi, L. (2021).  Drug-induced liver injury associated with pexidartinib treatment for tenosynovial giant cell tumor. The American Journal of Gastroenterology. 116(S1120). doi: 10.14309/01.ajg.0000784220.06220.28 

Manuscript Pending Publication

- Journal of Clinical Orthopaedics and Related Research(CORR)

1. Volaski, H., Brook, A., Viscarret, V., Wang, J., Singh, S., Yang, R., Hoang, B., Tingling, J., Al-Hardan, W., Zhang, R., Thornhill, B., Geller, D. (2021). Benign Bone Lesions. CORR. submitted.

- Journal of Scientific Reports

2. Zhang, Z.,  Wang, Y., Piperdi, S., Zhang, W., Tian, W., Roth, M., Gill, J., Harrison, D., Wang, J., Ivenitsky, D., Lazar, A., Yang, R., Geller, D., Hoang, B., Gorlick, R. (2021). Transformation of human osteoblasts with a combination of hTERT, SV40 TAg, and c-Myc induces changes in phenotype and tumorigenic capability. Scientific Reports. Submitted.
3. Schneider, P., Ghert, M. et al. (2021). Surveillance After Extremity Tumor Surgery (SAFETY): a multi-center randomized controlled study comparing how the frequency and mode of surveillance affect patient survival following extremity STS surgery using CT scan versus chest radiograph imaging modalities every three months versus every six months- Pilot Study.

Acknowledgement of R01Grant Submission

1. Hoang, B. Principal Investigator, grant titled Leveraging Tumor Suppressor Inactivation for Osteosarcoma Therapy was funded by the National Institute of Health/National Cancer Institute (R01 CA255643) from 7/1/201-6/30/2025. This grant will support the preclinical studies for the role of SCF complex in tumor suppressor Rb1/Tp53-inactivated osteosarcoma.

Invited Lectures/Presentations

1. Geller D. Lumps, Bumps and Sarcomas: How to Manage Extremity Masses and Avoid Dangerous Unplanned Excisions.  American College of Surgeons Clinical Congress. Virtual. October 23-27, 2021.